Pierre Fabre Medicament - Active Ingredient Division, offers its services from chemical development to commercial production of APIs in compliance with cGMPs. Our main expertise is the extraction and purification of natural products and cytotoxic API manufacture. We also provide a wide range of services in Bioavailability and stability enhancement using SuperCritical CO2. Three main technologies have been developed: Nanoparticles manufacture by RESS and SAS processes to increase the API dissolution rate and API/Cyclodextrins complexation (Formulplex, patented technology) to increase the API solubility, both processes are carried out in Supercritical medium. An innovative technology enables the coating of Nano size particles at room temperature with no organic solvent (Formulcoat, patented technology).
