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Grignard Reaction
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The Grignard reaction, named for the French chemist François Auguste Victor Grignard, is an organometallic chemical reaction in which alkyl- or aryl-magnesium halides (Grignard reagents), which act as nucleophiles, attack electrophilic carbon atoms that are present within polar bonds (e.g., a carbonyl group, see below) to yield a carbon-carbon bond (compare to Wittig reaction), thus altering hybridization about the reaction center.[1] The Grignard reaction is an important tool in the formation of carbon-carbon bonds[2][3] and for the formation of carbon-phosphorus, carbon-tin, carbon-silicon, carbon-boron and other carbon-heteroatom bonds.


 
Encyclopedia of Custom Chemical Manufacturing
The addition to the nucleophile is irreversible due to the high pKa value of the alkyl component (pKa = ~45). Grignard reagents react with electrophilic chemical compounds. It should be noted that suc...
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